Distribution-based estimates of minimum clinically important difference in cognition, arm function and lower body function after slow release-Ampyra (fampridine) treatment of patients with MS: STUDY

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To provide distribution-based estimates of the minimal clinical important difference (MCID) after slow release fampridine treatment on cognition and functional capacity in people with MS (PwMS).

MCID values were determined after SR-Fampridine treatment in 105 PwMS. Testing included the Timed 25 Foot Walk (T25FW), the Symbol Digit Modalities Test (SDMT), the Six Spot Step Test (SSST), the 9-Hole-Peg-Test (9-HPT), and the 5-Time-Sit-To-Stand test (5-STS).

MCID values: T25FW 17.8% (9.1–17.8), SDMT 17.1% (9.2–17.1), SSST 16.7% (8.5–16.7), 9-HPT 15.3% (0–15.3), and 5-STS 34.6% (16.9–34.6).

This study presents distribution-based estimates of MCID values for the SSST, the 9-HPT, and the 5-STS and confirms MCID estimates for the T25FW and the SDMT.

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